Recently, scientists from the United States and Sweden, through the study found a new control point (a kinase anchoring proteins), and this may help provide for the treatment of diabetes or certain metabolic diseases. A kinase anchoring proteins, or AKAPs is known to affect a protein the cellular kinase dimensional dispersion, of course, this protein is also the control and the body's blood sugar regulation related to one of the important events enzymes.

The study, published in the internationally renowned magazine The EMBO Journal, researchers for the first time reveals AKAPs spatial orientation through the coordination of phosphate enzyme to influence the body's blood sugar levels phosphatase is a naturally occurring enzymes, can the effect brought by the neutralization and kinase. Researchers said John Scott, our findings reveal the contribution of the anchoring enzymes for cells regulate events, which may help us to seek rapid treatment of diabetes or metabolic disease therapies. Findings reveal AKAP 150 anchor role protein plays in the control of glucose metabolism and related metabolic disorders, post-anchored proteins, we can target to design new drugs to interfere with its function, to treat disease.

The researchers used imaging technology and the insulin-secreting cells separating genetic modification technology by mouse study, to investigate the anchoring protein for the mouse glucose metabolism and insulin release effects. The study found that lack of encoding AKAP 150 anchor protein gene in mice will produce less insulin in the islet area, however, researchers good handle due to the lack of target tissue in skeletal muscle insulin sensitivity increase triggered insulin secretion in mice The results show that these effects are caused due to the 7 amino acid sequence in the anchor protein can interact directly with the surface of phosphatase.

The release of insulin is the principal means of regulating the glucose level of the body. In the future, we may develop new drug targets this seven amino acid sequence region, directly phosphatase role, if you can, this will improve in the the selective tissue such as skeletal muscle insulin sensitivity . The study shows a molecular control point is very clear for us, this may provide some idea of ​​the clinical treatment of diabetes or certain metabolic diseases.

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