August 03, 2012

German found a bacterial toxin that can lead to cell suicide

German researchers found that a bacterial toxin can cause a protein inactivation within the cell, resulting in cell "suicide". This finding helps to study how to kill cancer cells. Related paper was published in "Journal of Biological Chemistry". Germany University of Freiburg, issued a press statement on August 1 that, university researchers found a kind of toxincalled "Tpel” in Clostridium perfringens, which can lead to gas gangrene. The toxin can cause sugar molecules attached to Ras proteins in the host cell to interfere with the natural functions of this protein. Pharmacologist Klaus, Aketorresfrom University of Freiburg told us that , Ras protein in human cells play an important role in stimulating cell growth, the toxin Tpel will change this protein to fail to promote cell growth, ultimately leading to cell death. It often occurs Ras protein mutation In human cancer cells, and this protein plays an important role in cancer formation.If target the variant Ras protein in the cells, and we can perhaps use such toxins lead to cancer cells "suicide." The researchers are now conducting further studies.

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