January 03, 2013

Branch geometric induced lung automatic adjustment of growth.

Branch morphogenesis is a widely distributed in natural phenomenon. In organogenesis, which results in uneven growth, leading to the epithelium single branch into the surrounding mesoderm repeat. Lung morphogenesis is a landmark case, tree organogenesis the most common mammals. The core network is very sure, especially Fgf10 / SHH couples, need to start and the maintenance branch. In the previous study, we show that limit Fgf10 expression domain hiss distal interstitial spontaneously entice differential epithelial hyperplasia lead to branch. A simple Laplacian model copy FGF10 qualitative dynamic interstitial and spontaneous self avoid branch morphogenesis. However, the early lung cancer geometry several conspicuous features, remain to be resolved. In this paper, we mainly research, through the simulation and analysis of data, if FGF10 - diffusion in the scene of the following aspects of the lung morphology: size dispersion, asymmetric branch events and distal epithelium mesothelium balance. We report said, they appear in the model of spontaneous, and most of the bottom mechanism can be understood as dynamic gradient and the interaction between the shape. This shows that the specific provisions may not need these emergent compelling geometrical characteristic

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