Depression is two times of women compared with men. In bipolar disorder, depressive episodes in female patients reported more common. In addition, depression often and hormonal fluctuations period. Hormone signal connection between these emotional obstacles, therefore, is considered in many studies. Estrogen, a major female hormone, and its effect mainly by binding to estrogen receptors (ERs). Nuclear ers function as a transcription factor and regulating gene transcription is bound to a specific DNA sequence. A nucleotide changes may change the binding of binding sequence efficiency, this may affect the adjacent gene transcription level. To investigate if the variable ER DNA binding sequence may be involved in emotional obstacles, we performed a genome-wide research the patient's ER DNA binding diagnosed with depression or bipolar disorder. Association study in each gender separately, the result is more than the correct Bonferroni test method. In the women's bipolar affective disorder material significant results are found rs6023059 association (correction p-value = 0.023; odds ratio (or 0.681, 95% confidence interval (CI) 0.570-0.814), a single nucleotide polymorphisms (SNPS) placed tream genes encoding transglutaminase 2 (TGM2). Therefore, women with a specific genotype in the SNP may be more prone to fluctuation of estrogen level, which can act as a trigger factors on bipolar affective disorder.

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