Appropriate lung function not only need a proper structure of conductive airway tree, but also the development of the smooth muscles and blood vessels. Lung branch morphogenesis strong rigidity and includes recursive use only three kinds of modes of the branch. We've confirmed that the interaction between the description fibroblast growth factor (FGF) 10, sonic hedgehog (SHH) and repair (Ptc) can produce a Turing machine system, not only breeding experimental observation to the wild type branching pattern, part of the reason is counterintuitive, pattern in the mutant mice. Here we show that although many protein influence the formation of smooth muscle and Vegfa expression, an inducer formation of blood vessels, it is enough to FGF9 added to the FGF10 / boo/Ptc module successfully predicted at the same time appear smooth muscle growth between crystallization, Vegfa lung bud expression in the distal joint epithelial cells stroma. Our model reproduces the phenotype, and related mutant mice wild type, and most of the culture conditions described in the literature

Posted by: biomichael825 at 12:25 PM | No Comments | Add Comment
Post contains 191 words, total size 1 kb.