Endocrine disorders that affect coagulation and fibrinolysis system and related the development of cardiovascular disease. Thrombin increase can activate fibrinolysis inhibitors (TAFI) is a link between coagulation and fibrinolysis system. The purpose of this study was to determine the effect of thyroid hormone excess and lack of in TAFI level and function. In TAFI hyperthyroxinemia was studied in healthy volunteers were randomly assigned to accept left-hand thyroid hormone or no drug treatment for 14 days in crossover design. In TAFI hypothyroidism was studied in a multi-center observational cohort study. Pumping blood therapy patients before, when euthyroidism newly diagnosed the hypothyroidism. Plasma clot dissolution time, activation TAFI (tower Philippines and wine) depend on the extended blood clot dissolved and TAFI level measurement. Thyroid hormone excess lead to hypofibrinolytic conditions and in an enhanced tower Philippines and alcohol dependence extended blood clot dissolved. The trend of decline TAFI observation plasma levels in healthy volunteers use left-hand thyroid hormone. Hypothyroidism cause hyperfibrinolysis and reduce the tower Philippines and alcohol dependence extended blood clot dissolved. In a word, the change of the tower Philippines and alcohol dependence extended blood clot dissolved in patients with thyroid disease may lead to a damaged hemostatic balance. In the disturbance hemostatic patients balance hyperthyroidism may make them easy to thrombosis, and the risk of bleeding may increase patient hypothyroidism.

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