December 11, 2012
Methyl mercury is an environmental pollutant, poisonous central nervous system; However, its toxic molecules mechanism is not clear. Methyl mercury increase several chemokine expression in cerebellar mice and methyl mercury. This study analyzed the potential of the methyl mercury induced chemokine expression mechanism use human 1321 n1 astrocytes, and display, methyl mercury increases in these cells CCL2 expression. The transcription factor nf-kappa B is involved in induced chemokine expression. Methyl mercury levels increase the nf-kappa B p65 subelement in the nuclei of 1321 n1 cell. Methyl mercury cause increase significantly reduce the CCL2 expression inhibition p65 expression by RNA interference. The results show that methyl mercury cause the nf-kappa B chemokine expression through the activation in human astrocytes
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