It has been put forward, the tooth agenesis and cancer development has a common molecular pathways. We conducted a cross-sectional study survey of molecular epidemiology and the correlation between and readme teeth agenesis of the cancer family history. Eighty-two people with tooth agenesis and 328 people do not have the same institution of recruiting birth defects. Teeth dysplasia is evaluation in permanent teeth and definition based on participants' age, when the initial form teeth should radiology visible. We also investigated the action of the genes involved in dental development involved in tumorigenesis and 14 mark, FGF3 AXIN2, FGF10, FGFR2 were genotyped. Teeth agenesis people have greater risks have a family history of cancer (p = 0.00006; or = 2.7; 95% ci, 1.6 to 4.4). A connection between AXIN2, FGF3, FGF10, and teeth agenesis (or FGFR2. Personal carry polymorphism allelic FGFR2 (rs1219648) puts forward higher risk have premolar hypoplasia (p = 0.02; or = 1.8; 95% ci, 1.1-3.0)]. In a word, the tooth dysplasia is and positive self report of cancer family history and variant in AXIN2, FGF3,FGF10, FGFR2. Prospective study is needed to confirm if the teeth agenesis can be used as a risk marker for cancer.

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