Transglutaminase 2 and the nf-kappa B: a strange couples, shape breast cancer phenotype.

Because many professional survival target genes, abnormal activation of the nf-kappa B transcription factor is a kind of drug resistance phenotypic correlation and aggressive breast cancer behavior. 

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, a ubiquitously expressed protein crosslinking enzyme, activate the nf-kappa B through the unconventional mechanism, disable I κ B α inhibitors. Our company recently records, TG2 genes (known as TGM2) is a direct nf-kappa B transcription goal. These development uncover a self-enforcing molecular feedback loop, novel nf-kappa B TG2 activation, in turn, the nf-kappa B direct upregulates TGM2 transcription. The manuscript of the literature review, support are TG2 / nf-kappa B signal cycle, nature of the signal transduction, activate the circulation, and phenotypic consequences from abnormal activation of the novel signal mechanism in breast cancer

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